IL12/23 (p40), IL23, IL12 (p70) antibody

Catalog No. ABIN6963860

This Mouse Monoclonal antibody specifically detects in ELISA and ELISpot. It exhibits reactivity toward Human and Non-Human Primate and has been mentioned in 4+ publications.

Quick Overview for IL12/23 (p40), IL23, IL12 (p70) antibody (ABIN6963860)

Target: IL12/23 (p40), IL23, IL12 (p70)

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Application: ELISA, ELISpot

Clone: MT86-221

Product Details

Specificity: Native and recombinant p40 subunit of IL-12 and IL-23. The antibodies recognize p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40+p35) and IL-23 heterodimer (p40+p19).

Cross-Reactivity (Details): The monoclonal antibodies cross-react with the p40 subunit of IL-12 and IL-23 from non-human primates.

Characteristics: These monoclonal antibodies enable specific detection of the p40 subunit of human IL-12 and IL-23 in immunoassays such as ELISpot, FluoroSpot, and ELISA. Serum/Plasma samples

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human IL-23

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Is recommended as capture mAbs in ELISpot, FluoroSpot, and ELISA for analysis of: IL-12/-23 (p40) in combination with mAb ABIN6963861 and ABIN7448304 .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References

Pourakbari, Hosseinpour Sadeghi, Mahmoudi, Parvaneh, Keshavarz Valian, Mamishi: "Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection." in: Allergologia et immunopathologia, Vol. 47, Issue 1, pp. 38-42, (2019) (PubMed).

Iaconelli, Lemetais, Kechaou, Chain, Bermúdez-Humarán, Langella, Gervais, Beney: "Drying process strongly affects probiotics viability and functionalities." in: Journal of biotechnology, Vol. 214, pp. 17-26, (2016) (PubMed).

Myers, Cooper, Kem, Stavrakis, Kosanke, Shevach, Fairweather, Stoner, Cox, Cunningham: "Cardiac myosin-Th17 responses promote heart failure in human myocarditis." in: JCI insight, Vol. 1, Issue 9, (2016) (PubMed).

Mohanram, Sköld, Bächle, Pathak, Spetz: "IFN-α induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3346-53, (2013) (PubMed).

Target Details

Target: IL12/23 (p40), IL23, IL12 (p70)

Gene ID: 3592, 3593